Gene information
Official symbol BDNF
Official full name brain derived neurotrophic factor
Gene type protein-coding gene
Chromosome11p14.1
Gene familyNeurotrophins
Resources
Entrez Gene 627
HGNC HGNC:1033
Ensembl ENSG00000176697
Vega OTTHUMG00000178797
UCSC uc001mrz.5
GO terms: 64 records
GO Description Category LogP Number of genes Detail
GO:0001558 regulation of cell growth GO Biological Processes -19.1123936 65 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0007610 behavior GO Biological Processes -18.1916656 76 More
GO:0007611 learning or memory GO Biological Processes -7.55755517 33 More
GO:0007613 memory GO Biological Processes -4.31484432 16 More
GO:0008361 regulation of cell size GO Biological Processes -4.6524989 21 More
GO:0010720 positive regulation of cell development GO Biological Processes -17.713649 52 More
GO:0010975 regulation of neuron projection development GO Biological Processes -5.89330331 41 More
GO:0010976 positive regulation of neuron projection development GO Biological Processes -4.13061709 18 More
GO:0016049 cell growth GO Biological Processes -4.37315767 14 More
GO:0030307 positive regulation of cell growth GO Biological Processes -13.7154299 34 More
GO:0030424 axon GO Cellular Components -6.14132550 54 More
GO:0030425 dendrite GO Cellular Components -4.55233052 48 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0031175 neuron projection development GO Biological Processes -7.36986002 58 More
GO:0031344 regulation of cell projection organization GO Biological Processes -8.91314416 62 More
GO:0031346 positive regulation of cell projection organization GO Biological Processes -6.78114948 37 More
GO:0032535 regulation of cellular component size GO Biological Processes -4.60941253 33 More
GO:0032989 cellular component morphogenesis GO Biological Processes -4.92421328 47 More
GO:0033138 positive regulation of peptidyl-serine phosphorylation GO Biological Processes -6.77396219 11 More
GO:0034330 cell junction organization GO Biological Processes -7.96624809 49 More
GO:0040007 growth GO Biological Processes -14.0580178 53 More
GO:0040008 regulation of growth GO Biological Processes -30.7609323 104 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0043523 regulation of neuron apoptotic process GO Biological Processes -14.5388618 39 More
GO:0043524 negative regulation of neuron apoptotic process GO Biological Processes -11.6647584 29 More
GO:0044089 positive regulation of cellular component biogenesis GO Biological Processes -10.7794496 56 More
GO:0045596 negative regulation of cell differentiation GO Biological Processes -26.9785067 101 More
GO:0045927 positive regulation of growth GO Biological Processes -20.3035639 52 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048471 perinuclear region of cytoplasm GO Cellular Components -8.50169248 66 More
GO:0048588 developmental cell growth GO Biological Processes -4.47857706 14 More
GO:0048589 developmental growth GO Biological Processes -14.0580178 53 More
GO:0048638 regulation of developmental growth GO Biological Processes -23.5012496 63 More
GO:0048639 positive regulation of developmental growth GO Biological Processes -14.4198804 35 More
GO:0050767 regulation of neurogenesis GO Biological Processes -15.7439029 55 More
GO:0050803 regulation of synapse structure or activity GO Biological Processes -6.38009123 27 More
GO:0050804 modulation of chemical synaptic transmission GO Biological Processes -15.2260557 60 More
GO:0050807 regulation of synapse organization GO Biological Processes -6.08931613 26 More
GO:0050808 synapse organization GO Biological Processes -6.17744712 32 More
GO:0050890 cognition GO Biological Processes -8.00500082 37 More
GO:0051099 positive regulation of binding GO Biological Processes -11.1715489 31 More
GO:0051960 regulation of nervous system development GO Biological Processes -17.2202851 64 More
GO:0060284 regulation of cell development GO Biological Processes -22.9455891 78 More
GO:0060341 regulation of cellular localization GO Biological Processes -10.5933083 72 More
GO:0061387 regulation of extent of cell growth GO Biological Processes -3.21598264 13 More
GO:0070848 response to growth factor GO Biological Processes -40.6139195 102 More
GO:0071363 cellular response to growth factor stimulus GO Biological Processes -39.8883675 98 More
GO:0097447 dendritic tree GO Cellular Components -4.82959150 49 More
GO:0098793 presynapse GO Cellular Components -4.56552653 42 More
GO:0099177 regulation of trans-synaptic signaling GO Biological Processes -15.1793607 60 More
GO:0120035 regulation of plasma membrane bounded cell projection organization GO Biological Processes -8.54789693 60 More
GO:1901214 regulation of neuron death GO Biological Processes -23.5458880 37 More
GO:1901215 negative regulation of neuron death GO Biological Processes -19.0527525 45 More
GO:1901888 regulation of cell junction assembly GO Biological Processes -8.71146171 30 More
GO:1901890 positive regulation of cell junction assembly GO Biological Processes -5.75086352 17 More
GO:1990089 response to nerve growth factor GO Biological Processes -1.87243811 6 More
GO:1990090 cellular response to nerve growth factor stimulus GO Biological Processes -1.96182882 6 More
GO:2001233 regulation of apoptotic signaling pathway GO Biological Processes -35.8481080 51 More
GO:2001234 negative regulation of apoptotic signaling pathway GO Biological Processes -32.1748782 40 More
KEGG pathways: 6 records
KEGG Description Category LogP Number of genes Detail
hsa04010 MAPK signaling pathway KEGG Pathway -13.6331973 26 More
hsa04014 Ras signaling pathway KEGG Pathway -9.01898803 33 More
hsa04024 cAMP signaling pathway KEGG Pathway -7.78464854 30 More
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
hsa05016 Huntington disease KEGG Pathway -1.30792988 8 More
hsa05022 Pathways of neurodegeneration - multiple diseases KEGG Pathway -4.18311884 18 More
Drug-Gene interaction
view
Related drugs: 64 records
Drug name Interaction type Source PMID View
alteplase NCI 1881527018563704 view
baclofen NCI 17074039 view
bortezomib NCI 15657181 view
camptothecin NCI 10428835 view
capsaicin NCI 10430952 view
cetuximab NCI 16651634 view
chlorpromazine NCI 18408624 view
citalopram PharmGKB 22965830213386492373303023619509192367302974886220016225 view
colchicine NCI 1946455 view
corticotropin NCI 16330021 view
curcumin NCI 1761738818420184 view
desipramine PharmGKB view
diacetylmorphine PharmGKB 242798592869241826401760 view
didanosine NCI 17616550 view
diethylstilbestrol NCI 17292805 view
donepezil NCI 17990049 view
doxorubicin NCI 10728907 view
dronabinol NCI 15857384 view
epoetin beta NCI 15816864 view
escitalopram PharmGKB 19641488 view
fluorouracil NCI 18702703 view
fluoxetine PharmGKB 20016225 view
flurbiprofen NCI 16531049 view
gemfibrozil NCI 17823123 view
gentamicin NCI 10536212 view
glucagon NCI 17924870 view
haloperidol NCI 12393228 view
imipramine NCI 16522641 view
indomethacin NCI 16956981 view
inositol NCI 16286649 view
insulin NCI 929956516650607 view
ionomycin NCI 12038986 view
k-252a NCI 16797499 view
levodopa NCI 15081599 view
lidocaine NCI 16210356 view
liothyronine sodium NCI 8288635 view
lithium NCIPharmGKB 1630080324885933 view
methadone NCIPharmGKB 2365102418182069 view
methamphetamine PharmGKB 242798592869241826401760 view
methylprednisolone NCI 14966352 view
metyrosine NCI 16390493 view
mifepristone NCI 17464718 view
naloxone NCI 12359151 view
nicardipine NCI 10748141 view
nicotine NCI 16790237 view
nortriptyline PharmGKB 19641488 view
nystatin NCI 12941963 view
olanzapine PharmGKB 24595507 view
paclitaxel NCI 16778834 view
paroxetine PharmGKB 22965830213386492373303023619509192367302974886220016225 view
pilocarpine NCI 15183516 view
propranolol NCI 15598146 view
propylthiouracil NCI 11077070 view
simvastatin NCI 18047562 view
sodium chloride NCI 12742641 view
sumatriptan PharmGKB 25096645 view
thyroglobulin NCI 8895887 view
topotecan NCI 15569250 view
tramadol NCI 15464068 view
troglitazone NCI 17924870 view
vasopressin NCI 16457953 view
venlafaxine NCI 14978196 view
verteporfin NCI 15505074 view
vincristine NCI 15569250 view
Related studies: 6 records
Molecular factor Omics type Application Objective MI type Reference
brain-derived neurotrophic factor proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Lorgis L et al. Fundam Clin Pharmacol. 2010
brain-derived neurotrophic factor proteomics good predictor acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Zhang Y et al. Cytokine. 2015
brain-derived neurotrophic factor proteomics good predictor acute heart failure[prognosis (bad)] acute ST elevation myocardial infarction Wu H et al. Med Sci Monit. 2019
brain-derived neurotrophic factor proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Montone RA et al. Epub ahead of print. 2020
brain-derived neurotrophic factor proteomics healed plaques[prognosis (good)] acute myocardial infarction Montone RA et al. Epub ahead of print. 2020
brain-derived neurotrophic factor proteomics macrophage[other] acute myocardial infarction Montone RA et al. Epub ahead of print. 2020
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